Mgm101: A double-duty Rad52-like protein
نویسندگان
چکیده
منابع مشابه
Mgm101: A double-duty Rad52-like protein
Mgm101 has well-characterized activity for the repair and replication of the mitochondrial genome. Recent work has demonstrated a further role for Mgm101 in nuclear DNA metabolism, contributing to an S-phase specific DNA interstrand cross-link repair pathway that acts redundantly with a pathway controlled by Pso2 exonuclease. Due to involvement of FANCM, FANCJ and FANCP homologues (Mph1, Chl1 a...
متن کاملRECQ1's double duty
Why are cel ls so tense? C ells might be able to rapidly adjust their stiffness by contracting myosin motors, according to a new cytoskeleton model from Daisuke Mizuno, Christoph Schmidt (Georg-August-Universität, Göttingen, Germany), and colleagues. Cells adjust their rigidity when they interact with the extracellular matrix, for example, and when an external force acts on them. To mimic cytos...
متن کاملGle1 Does Double Duty
During nuclear export, Gle1 (the nuclear-pore-associated mRNA export factor) activates the DEAD-box protein Dbp5 to remodel exported mRNA-protein complexes on the cytoplasmic face of the nuclear pore complex. In this issue, Bolger et al. (2008) now report additional roles for Gle1 in translation initiation and termination.
متن کاملChromatin Proteins Do Double Duty
The histone acetyltransferase MOF (males-absent-on-the-first) is required for the regulation of X chromosome gene dosage compensation in Drosophila males. In this issue, Kind et al. (2008) show that MOF is also found on autosomes and that it has two modes of binding: one in males for X chromosome dosage compensation and the other in both sexes for X chromosome and autosomal gene regulation inde...
متن کاملIdentification of plant RAD52 homologs and characterization of the Arabidopsis thaliana RAD52-like genes.
RADiation sensitive52 (RAD52) mediates RAD51 loading onto single-stranded DNA ends, thereby initiating homologous recombination and catalyzing DNA annealing. RAD52 is highly conserved among eukaryotes, including animals and fungi. This article reports that RAD52 homologs are present in all plants whose genomes have undergone extensive sequencing. Computational analyses suggest a very early RAD5...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Cycle
سال: 2016
ISSN: 1538-4101,1551-4005
DOI: 10.1080/15384101.2016.1231288